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The focus here is on the expectation and events surrounding Christ’s return. First and Second Thessalonians are the pair that center most clearly on the Second Coming, including what will happen to believers and how they should live in light of that hope. In the first letter, Paul comforts believers with the truth about the coming of the Lord, the resurrection of the dead, and the believers being caught up to meet Him. The second letter expands on that eschatological theme, clarifying misunderstandings about the Day of the Lord and urging steadfast living as they await Christ’s return, even addressing signs and the rise of the lawless one.

Other pairs don’t prioritize the Second Coming as their dominant focus: Romans and Galatians emphasize justification by faith and the gospel’s righteousness apart from works; Ephesians and Colossians stress church unity, cosmic reconciliation, and practical Christian living; Philippians and Philemon center more on personal relationships, joy, and daily conduct. So the Thessalonian letters are the best match for the major theme of Christ’s return.